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本所各实验室之研究兴趣及领域(Research Interests)如下:

药物设计与系统生物实验室  ( BioXGEM – PI: Dr. Jinn-Moon Yang )

  • Protein-Ligand Docking / Virtual Drug Screening (GEMDOCK)
  • Computer-aided Drug Design (QSAR/Toxicity prediction) (GEMDOCK)
  • Systems Biology: Protein-Protein (Protein-DNA) Interaction/Docking & Pathway (DAPID)
  • Protein Folding [(PS)2] & Structural Bioinformatics (3D-BLAST)
  • Machine Learning and Applications: Genetic algorithms, evolution strategies, and evolutionary programming
  • Structure prediction and classification
  • Prediction of protein subcellular localization
  • Disulfide proteins
  • Protein stability
  • Structural alignment
  • Molecular Simulation
  • Sequence coupling      
  • Systems Biology: gene regulatory network, optimization of energy function
  • Computational Biology: protein structural prediction, protein-ligand docking
  • Microarray analysis: Gene expression data analysis, Feature selection and classification
  • Evolutionary Computation: intelligent evolutionary algorithms, optimization problem solving
  • Machine Learning: pattern recognition, data mining, artificial intelligence
  • Optimization theory: combinatorial optimization, optimization of large-scale systems
心脏电气学及心血管生物资讯学实验室 (Electrocardiology and Cardiovascular Bioinformatics Lab – PI: Dr. Ten-Fang Yang)
Time domain and frequency domain Signal Averaged ECG
  • Clinical Application of Heart Rate Variability
  • Medical Image Processing in Cardiology
  • Non-Invasive Cardiology
  • Electrocardiology
  • Standard 12-lead electrocardiography
  • Frank and Derived Vectorcardiography
  • Parametric Modeling of SAECG
  • We are interested in the design and analysis of algorithms, including bioinformatics algorithms, combinatorial optimization algorithms and graph algorithms, and the development and applications of bioinformatics software tools. Current research topics in our lab include sequence alignment, genome rearrangement, evolutionary tree prediction, RNA/Protein structural prediction and comparison, etc.
  • Synthetic and Systems Biology
  • microRNA regulation
  • Post-transcriptional regulation and RNA processing
  • Post-translational modification (PTM)
  • Proteomics
  • Theoretical coordination chemistry
  • Studies in spectroscopy
  • Benchmark in high-performance computing
  • Dr. Lin’s lab is interested in developing and applying methods and tools in Bioinformatics to study various problems in Genomics, Structural Biology, and Evolutionary Biology.
  • Cellular morphogenesis is the process by which the size or shape of a cell is generated and organized to adapt to certain developmental or environmental changes. The Hwang lab is particularly interested in a morphogenetic process termed neuritogenesis, through which a nerve cell generate its elongated axon and dendrites. It is the fundamental process underlying the establishment and plasticity of neuronal networks. Neuritogenesis can be generally categorized into several distinct steps: neurite initiation, neurite elongation, axonal polarization and growth, dendritic growth, and axon/dendrite maturation.